We had an inkling when Mr. and Mrs. Smith opened with Alexander Skarsgård and then unceremoniously disposed of him within the first three minutes: this show had serious guest star juice. By episode two, when Paul Dano casually dropped in as a passive-aggressive neighbor, a pattern had clearly emerged.
Mr. and Mrs. Smith, the 2024 Prime Video series (based loosely on Mr. and Mrs. Smith, the 2005 movie that launched Brangelina into the world), stars Donald Glover and Maya Erskine as John and Jane Smith. The two are matched together by a mysterious organization to start a new life in which they pose as a married pair of software engineers while actually working as assassins and handlers of otherwise unsavory, high-risk tasks.
Glover and Erskine serve as the emotional center of the story, and witnessing their relationship evolve is the one constant throughout. But in each episode, there’s also some new, unexpected high-wattage talent introduced, one of the many ways in which the show constantly winks at the viewer.
From a perverted John Turturro to a wimpy Ron Perlman, here’s the exhaustive guide to the most stacked guest star cast on TV.
Alexander Skarsgård and Eiza González as Other John and Jane — Episode 1
The show opens with Skarsgård and González as a preternaturally sexy couple hiding away in a shack in the middle of the woods. They’re also named John and Jane, and presumably on the run from their responsibilities. Despite their arsenal of weapons, they meet a quick end at the hands of two mysterious assassins. (Though if you’ve made it all the way through the series, you have a better idea of who—or, to be specific, which bob haircut—took them out.) This clears the way for the Glover and Erskine John-and-Jane pairing to take the stage.
Paul Dano as Hot Neighbor — Episodes 2 and 8