Colorado vs. Oregon prediction, odds, spread, line, time: Top expert picks for Deion Sanders Pac-12 debut

Head coach Deion Sanders and the No. 19 Colorado Buffaloes (3-0) hit the road to take on the No. 10 Oregon Ducks (3-0) on Saturday at Autzen Stadium. This game will be the Pac-12 debut for Coach Prime and Heisman Trophy contender Shedeur Sanders. The Buffs are coming off a 43-35 double overtime win over Colorado State in the Rocky Mountain Showdown. Oregon is looking to bolster its College Football Playoff resume and quiet the hype train that follows Sanders and Colorado wherever they go. Last week the Ducks knocked off Hawaii 55-10 behind three touchdown passes from fifth year senior Bo Nix, another Heisman contender. Oregon has won nine of the past 10 meetings with Colorado.

Kickoff is at 3:30 p.m. ET at Autzen Stadium in Eugene. The SportsLine consensus Colorado vs. Oregon odds list the Ducks as 21-point favorites, while the over/under is set at 70. Before making any Oregon vs. Colorado picks or bets, be sure to check out the college football predictions and betting advice from SportsLine football expert Jimmie Kaylor. 

Kaylor is a NFL, college football, and DFS expert for SportsLine, who has covered the NFL and college football for close to a decade as a member of the Pro Football Writers of America. His background as a former college football All-American and NFL player gives him a unique perspective when building his fantasy lineups and locking in his betting picks. As a Colorado native, he has his finger on the pulse of the local and national sports scene and has been cashing big on Denver area teams for the last two years. 

Kaylor has been red-hot on his Colorado picks this season, going 4-1 on his best bets in the Buffs’ first three games of the season. Anyone who has followed his picks is way up.

Now, he has set his sights on Colorado vs. Oregon and just locked in its picks and CFB predictions. You can head to SportsLine now to see Kaylor’s picks. Here are several college football odds and betting lines for Oregon vs. Colorado:

  • Colorado vs. Oregon spread: Oregon -21
  • Colorado vs. Oregon over/under: 70 points
  • Colorado vs. Oregon money line: Oregon -882, Colorado +583
  • CU: QB Shedeur Sanders is averaging 417 passing yards per game
  • ORE: The Ducks are 7-1 at Autzen Stadium with Dan Lanning as head coach and Bo Nix at QB
  • Colorado vs. Oregon picks: See picks at SportsLine
  • Colorado vs. Oregon live stream: fubo (try for free)

Why Colorado can cover

Junior quarterback Shedeur Sanders has shown enough in his first three games at Colorado to insert himself into the Heisman Trophy race. With Sanders under center the Buffs are capable of scoring in bunches, and should be competitive in every game they play. Through three weeks, Sanders has completed 78.7% of his passes for 1,251 yards, 10 touchdowns and one interception. He’s also added one rushing touchdown.

The Buffs have surrounded Sanders with a bevy of explosive options to spread the ball around. Wide receivers Xavier Weaver (25 catches, 386 yards, 2 TDs) and Jimmy Horn Jr. (26 catches, 242 yards, 2 TDs), both South Florida transfers, and freshman running back Dylan Edwards (136 rushing yards, 1 TD, 14 catches, 160 receiving yards, 3 TD catches) have all flashed glimpses of elite level explosiveness in the Colorado offense. See which team to pick at SportsLine. 

Why Oregon can cover

The Ducks have a Heisman Trophy contender of their own in fifth-year senior Bo Nix, who is in his second season at Oregon after spending his first three at Auburn. In three games, Nix has completed 77.6% of his passes for 893 yards and eight touchdowns. He has yet to turn the ball over this season. For his career, Nix has 11,737 passing yards, 76 touchdowns and 23 interceptions. He’s also rushed for 1,439 yards and 32 TDs.

Nix plays behind one of the best offensive lines in the Pac-12. The Ducks have allowed their starting quarterback to be sacked one time in three games, and will face a Colorado defense that has struggled to put pressure on opposing quarterbacks. Wide receiver Troy Franklin has been a game changer for Oregon with 17 catches for 292 yards and three touchdowns this season. See which team to back at SportsLine. 

How to make Oregon vs. Colorado picks

Kaylor has analyzed this matchup from every angle and he’s leaning Over on the point total. He has also discovered a critical X-factor that has him jumping all over one side of the spread. He’s only sharing what it is, and which side to back, at SportsLine.

Who wins Colorado vs. Oregon in the Pac-12 debut for Deion Sanders, and which critical X-factor makes one side of the spread a must-back? Visit SportsLine now to see Colorado vs. Oregon picks, all from the expert who has covered college football for over a decade and is 4-1 on his Colorado best bets in 2023, and find out.

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