Michigan and Washington will meet in a rematch of last year’s National Championship Game in one of the top matchups on the Week 6 college football schedule. The programs may be at the beginning stages of a rivalry as well with Washington making its debut in the Big Ten this year. Washington is 3-2, including 1-1 in the Big Ten, under Jedd Fisch, who coached at Arizona last season. Michigan is 4-1 (2-0 Big Ten) under Sherrone Moore, who was on the Wolverines staff last season. Washington is a 2.5-point favorite at home, according to the latest Week 6 college football odds from the SportsLine consensus.
Washington has won 17 straight home games since the start of the 2022 college football season, so how should that affect your college football bets in a Week 6 college football schedule that also includes matchups such as No. 9 Missouri (+2.5) vs. No. 25 Texas A&M? Before locking in any Week 6 college football picks on those games or others, be sure to see the latest college football predictions from SportsLine’s proven model.
The model simulates every FBS college football game 10,000 times. Since its inception, it has generated a profit of well over $2,000 for $100 players on its top-rated college spread football picks. It also went a sizzling 6-0 on all top-rated college football picks in Week 5. Anyone who has followed it has seen strong returns.
Now, it has turned its attention to the latest college football odds and Week 6 college football betting lines on the spread, money line and over/under. Head here to see every pick.
Top college football predictions for Week 6
One of the college picks the model is high on during Week 6: Iowa (+19.5) stays within the big spread at No. 3 Ohio State in a 3:30 p.m. ET matchup Saturday on CBS. The Buckeyes chose to play a weak non-conference schedule this season, facing no real opposition through the first three weeks of the campaign. They opened conference play with a comfortable win at Michigan State, but they are facing a better opponent on Saturday.
Iowa is coming off its best performance of the season, cruising to a 31-14 win at Minnesota as a 2.5-point favorite. Junior running back Kaleb Johnson continued his phenomenal start, racking up 206 rushing yards and three touchdowns on 21 carries. He has finished with at least 119 rushing yards and two touchdowns in every game this season, and he is a big reason why the model has Iowa covering the spread in well over 50% of simulations. See the rest of its Week 6 college football picks here.
Another prediction: California (+10.5) plays a one-score game against No. 8 Miami in a 10:30 p.m. ET kickoff on Saturday. Cal is coming off its first loss of the season, falling to Florida State to drop to 3-1. Saturday will be the second time the Golden Bears are double-digit underdogs and they defeated Auburn, 21-14, on Sept. 7 as 12-point underdogs. The Bears have overachieved as a home underdog over the last few seasons though with a 6-2-1 ATS record in those scenarios since the start of the 2020 college football season.
Cal has one of the best defenses in the country, holding opponents to 12.7 points per game, which ranks ninth in college football. Defensive back Nohl Williams has four interceptions in four games and linebacker Teddye Buchanan has 40 tackles, including 2.5 sacks, to lead the stout defense as a key reason why Cal is covering the spread in 60% of simulations. See picks for every other game in Week 6 here.
How to make college football picks for Week 6
The model has also made the call on who wins and covers in every FBS matchup in Week 6, and it’s calling for a whopping seven underdogs to win outright, including an upset in one of the biggest games of the week. You can only get every pick for every game at SportsLine.
So what college football picks can you make with confidence, and which seven underdogs win outright in Week 6? Check out the latest college football odds below, then visit SportsLine to see which teams win and cover the spread, all from a proven computer model that has returned well over $2,000 in profit since its inception, and find out.
College football odds for Week 6
See full Week 6 college football picks, odds, predictions here
Thursday, Oct. 3
Texas State at Troy (+13.5, 57.5)
Sam Houston State at UTEP (+10.5, 50)
Friday, Oct. 4
Jacksonville State at Kennesaw State (+16.5, 48.5)
Houston at TCU (-16.5, 51.5)
Syracuse at UNLV (-6.5, 58.5)
Michigan State at Oregon (-24, 52.5)
Saturday, Oct. 5
Missouri at Texas A&M (-2.5, 48.5)
UCLA at Penn State (-27.5, 46)
Auburn at Georgia (-24.5, 52.5)
Ole Miss at South Carolina (+9.5, 53.5)
Iowa at Ohio State (-19.5, 44.5)
Alabama at Vanderbilt (+23.5, 55.5)
Clemson at Florida State (+14.5, 47.5)
Tennessee at Arkansas (+13.5, 59.5)
Baylor at Iowa State (-11.5, 45.5)
USC at Minnesota (+8.5, 51.5)
Michigan at Washington (-2.5, 41.5)
Miami at California (+10.5, 55)
Texas Tech at Arizona (-6.5, 64)
